The ISE6 cell line (Ixodes scapularis embryonic 6) is an extensively used tick cell line that has been successfully used to culture many tick-associated bacteria (Rickettsia, Anaplasma,Ehrlichia, and Neoehrlichia), to study vector-pathogen interactions and differential expression of pathogen genes during growth in mammalian and arthropod cells, to carry out growth and propagation of Arboviruses, and are an important model for molecular study using RNAi of tick genes important for decreasing pathogen transmission and understanding tick biology ( "An Ixodes scapularis cell line with a predominantly neuron-like phenotype", Oliver et al, Exp Appl Acarol. 2015 Jul; 66(3): 427–442. doi: 10.1007/s10493-015-9908-1).
Ixodes scapularis

Lyme disease tick, the black-legged or deer tick, Ixodes scapularis, is found in the Neartic region (Canada, USA and Mexico). In the USA Ixodes scapularis transmits Lyme disease, human granulocytic anaplasmosis, babesiosis and possibly Powassan Encephalitis.

Genome assemblies and gene sets